Total 2 science rd research job vacancies in Business Management / Project / Planning category in london se1 1na

Postdoctoral Project Research Scientist - Signalling and Structural Laboratory

Short summary
The Francis Crick Institute is recruiting a lab-based postdoctoral project research scientist to lead on the development of agonist antibodies that promote neuro-regeneration in neurological disease. The successful candidate will join the laboratory of Dr N.Q. McDonald (https://www.crick.ac.uk/research/labs/neil-mcdonald) and will collaborate with both the Neurodegeneration Biology Laboratory (https://www.crick.ac.uk/research/labs/sonia-gandhi) and Dom Bonnet at the Francis Crick Institute. The position is fully funded by the idea-to-innovation programme at the Crick to translate basic research findings into therapeutics.

The Research Group
The Signalling and Structural Biology Laboratory studies kinase-driven control mechanisms, assemblies and networks, focusing on processes such as neuro-regeneration, cell polarity and cell fate. Our goal is to understand how kinase control mechanisms are subverted in different human diseases. In parallel we have developed biological and chemical tools against neurotrophic and polarity protein kinase targets. In some cases, these tools have led to the development of lead clinical candidates (PMID: 23418854 & https://www.varianbio.com). Research techniques used in our multidisciplinary laboratory environment include cryo-electron microscopy, X-ray crystallography, cryo-electron tomography, biochemical and biophysical methods, chemical biology, cell culture models for neuronal differentiation and cell polarity.


Key Responsibilities
• To produce and characterise agonist antibodies and variants for use in dopaminergic neurons programmed from PD patient-derived iPSCs.
• To assess the potency of the antibody on different neuronal cell lines.
• Engage with collaborators to reformat the antibody and undertake a structure-guided antibody affinity maturation.
• To pilot trans-well experiments to assess antibody properties at crossing the blood-brain-barrier using an in vitro model.
• To act as the de facto project manager, liaising with collaborators and Crick service providers.
• To present results at internal meetings, conferences and, ultimately, to funders and investors.

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

Looking for your next analyst opportunity? Interested in transforming our ICT operating model?

About us
The Science Museum Group (SMG) is here to inspire futures. As the world's leading group of science museums, we share our unparalleled collection spanning science, technology, engineering, mathematics, and medicine with over five million visitors each year.

You will be joining a collaborative multi-disciplinary team, providing quality technical services to our customer and infrastructure operations along with project functions within ICT.

About the role
We're shaking things up with a new approach! Join us on a 12-month contract to lead and embed change, as we transition to light-touch analysis shared across our ICT function.

Bring your IT Analyst expertise to the table and assist us craft the training, support, and coaching necessary to make this shift seamless. You'll be instrumental in developing new toolsets and analysis templates that'll promote efficiency and innovation.

With our multi-site organisation amid various transformations, you'll have a plethora of projects, leading and enhancing each one with your skills and vision.

During your time with us, you will support the following activities -

1. Training of ICT staff in analysis.
2. Wi-Fi/Local Area Network pilot and start of implementation.
3. Wide Area Network replacement (end of contract).
4. E-commerce order fulfilment and stock storage/management.
5. Collections Management system requirements definition

This position offers the flexibility to work from home, on a hybrid basis, though some travel may be occasionally required to SMG sites, suppliers, and peer organisations.

We are reviewing applications as they come through which may influence our closing date, to avoid disappointment, we reccommend that you submit you interest as soon as possible.

Salary: £46,000 - £53,900 per annum

About you
With equal parts of business analysis experience, you have the skill to flex your style or communication to meet the needs of a range of activities. With this, you have a great aptitude in imparting your knowledge onto others, having developed colleagues in business analysis skillsets, as well as creating materials in the form of toolkits and templates.

We are looking for a true analyst and process improvement professional, rather than technical skill. Because of this, you will have significant experience of analysing business activities leading to client sign-off of requirement specifications.

You are customer-focused, approachable, organised and a good listener. Keen to get involved and a natural collaborator, you can work with people of all levels to establish a technical vision and to analyse the trade-offs between usability and functional and performance needs.

What we offer
Working with a world-leading museum group that offers access to truly unique environments and collections, you'll benefit from the perks listed below, as well as full support for life events such as parental and adoption leave, sickness, and career breaks.

• Meaningful work. We're a mission-led organisation where the work you do supports us in Inspiring Futures.
• Career growth. We offer enhanced support with personal and professional development.
• Work/life balance. We offer 27 days annual leave in addition to bank holidays, along with flexible policies which support you and your home life.
• Health & Dental Insurance. Extra peace of mind, from day one.
• All our colleagues can access an employee assistance programme, access to the Unmind app, and other wellbeing support.
• Enhanced contributory pension. To support you in saving for the future.
• Interest-free loans. When you need a little extra cash for life events or home improvements.
• Great discounts. Free entry to exhibitions, discounts in our shops, cafes, and access to other museums in the NMDC network.

Open for All is one of the Science Museum Group's five core values and sets out our important aspiration to be a place for everyone. We are working hard to understand our organisation better and to develop a culture that recognises and values different backgrounds, mindsets, skills, experience, knowledge, and expertise. By having greater diversity, we believe that we will be a stronger and better organisation, capable to continue to Inspire Futures.