Senior/Research Scientist - Mass spec
Full-time
Senior Executive
Slough, Berkshire, SL1 3WE, England
6 months ago
Job Title: Senior/Research Scientist - Mass spec Contract: 12 months Location: Slough Salary: £28.09 - 33.58 PAYE, £38.24 Umbrell.....
Job Title: Senior/Research Scientist - Mass spec
Contract: 12 months
Location: Slough
Salary: £28.09 - 33.58 PAYE, £38.24 Umbrella
SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team. This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.
Key Responsibilities will include:
- Structural and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
- proven track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
- manage and prioritise the demands from multiple projects.
Essential Requirements:
- PhD or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
- Experienced with Waters data processing software packages (PLGS) and DynamX™.
- Practical knowledge Waters HDX-MS system.
- Use of structural visualisation tools (PyMOL, Chimera or similar).
- Experienced with HDX-MS experiments using NBE and NCE molecules.
- Excellent organisational, communication, record keeping and team-working abilities.
Desirable Requirements:
- HDX-MS analysis of membrane proteins.
- Troubleshooting and maintenance of Waters LC/MS equipment.
- Practical ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
- Proven track record of publications related to mass spectrometry in peer reviewed journals.
- Appreciation of recombinant protein expression systems and PTMs.
- Working knowledge of Thermo Scientific Orbitrap MS systems.
Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.
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