Total 3 Junior Executive level Science / R&D / Research job vacancies in OX1 3RG

Full-time, Fixed term until 03 July 2027

Applications are invited for a Research Assistant neuronal cell biologist to work on a project to target calcium channels in Parkinson’s disease. The project, funded by the Michael J Fox Foundation and in collaboration with Lario Therapeutics, represents an exciting opportunity to undertake translation work at the interface between academic research and pharmaceutical target and drug discovery in an exceptional setting. This work will develop new inhibitors of calcium channels as a neuroprotective strategy to protect vulnerable dopamine neurons in Parkinson’s working with induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson’s patients.

Duties will include undertaking laboratory experiments; biochemistry, immunocytochemistry, cell and molecular biology; growth and differentiation of iPSC lines; interpretation of data; imaging analysis; and preparation of data for publication. You will have excellent practical experience of working with neuronal cell cultures and good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

Applicants must hold, or be near completion of, a BSc/MSc in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes.

The post is available immediately and runs until 03 July 2027. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3QU

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

Closing date for applications is midday on Monday 12th August 2024. Interviews are likely to be held in the week commencing 26th August 2024.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

Full-time, Fixed-term until 30th April 2027

Applications are invited for a Research Assistant to work on a highly collaborative and interdisciplinary project to develop transgenic rodent models of Parkinson’s disease. The work will support projects seeking to use rodent models of disease to understand the earliest stage of neurodegeneration at a point in which neuronal dysfunction precedes neuronal loss, offering an early therapeutic window for therapy. The post will be based in the Laboratory of Molecular Neurodegeneration in the Department of Physiology, Anatomy and Genetics, and is supported by the Wellcome Trust and an international consortium funded by an Aligning Science Across Parkinson’s (ASAP) grant.

Duties include colony management, breeding and maintenance of lines of transgenic rodents; collection of brain tissue for gene expression analysis; general laboratory management, preparation of data for publication; contributions to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have a good working knowledge of molecular and cellular biology, excellent practical experience of working with animal models and an interest in pre-clinical in vivo models of neurological disease. Previous experience of the management and maintenance of transgenic rodent lines would be an advantage. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is also essential.

Applicants must hold a BSc/MSc in a relevant area of research and will have excellent practical experience of working with animal models.

The fixed-term post is available immediately and until 30th April 2027. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, New Biochemistry, Phase 2, Parks Road, Oxford. Informal enquiries may be directed to Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk). Closing date for applications is midday on Wednesday 31st July 2024. Interviews are likely to be held in the week commencing 12th July 2024.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion.

Full-time, Fixed-term until 18 April 2025

The Cragg Group at the University of Oxford are seeking a Research Assistant to join a project funded by the MRC to explore the role of astrocytes in the regulation of dopamine function in health and parkinsonism.

The successful candidate will become a member of the Cragg group and will assist with studies to elucidate dopamine transmission, its regulation by astrocytes and related signaling molecules in mouse brain, in models of Parkinson’s disease. The candidate will have the opportunity to collaborate on projects with the Cragg Group’s internal and external partners and when appropriate, give advice and guidance to other members of the Group. The candidate will have responsibility for conducting, analyzing and interpreting scientific data generated from experiments, ensuring that the data are of the highest quality.

In addition to having, or nearing completion of, a first degree in a relevant science, candidates should have laboratory experience and some knowledge of the field of neuroscience. The candidate should also be able to manage their own research and administrative activities. The candidate needs experience of following and adapting protocols and selecting appropriate experimental methodologies. Experience of working with mice is desirable.

The post holder will work in the Group led by Professor Stephanie Cragg, and will be based at the Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT.

Closing date for applications is midday on Monday 15th January.

Interviews are likely to be held on the week beginning 29nd January.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion