Role Summary

Pfizer’s Machine Learning Hub is seeking a passionate, creative, and experienced machine learning researcher to design and implement new machine learning tools to accelerate drug discovery. As a member of our Machine Learning Research team, you will design new approaches to derive insights from Pfizer’s proprietary data and external datasets to generate testable hypotheses across the drug discovery continuum with a focus on extracting biological knowledge. The individual will also design, establish, and manage internal and external collaborations to advance Pfizer’s ML capabilities. The ideal candidate should have an outstanding scientific reputation in the field of machine learning research for computational biology and a demonstrated passion for solving biological problems relevant to drug discovery. Our team is located in Cambridge, MA, USA and Berlin, Germany and this role can accommodate an exceptional candidate in either location.

Role Responsibilities

Principal downstream application domains include indication expansion, target identification, disease mechanism elucidation, and partnering with practitioners in these areas to advance the state-of-the-art.

• Development and implementation of advanced machine learning models specifically designed for analyzing heterogeneous biological data. This includes data from genomics, proteomics, metabolomics, and other biological sources.
• Advance the internal machine learning tech stack to cope with spurious correlation, obscuring variation and inherent multimodality of biomedical, chemical, and ‘omics data
• Research, design and implement learning algorithms for analysis problems related to drug discovery
• Be an active member of a highly interdisciplinary team
• Conceive, execute and evaluate studies and experiments, interpret the results and present them to scientist in other functions
• Strengthen external visibility and scientific excellence through publishing / presenting work in reputed journals and conference/workshop venues and engaging with the scientific community

Qualifications

• Formal training in Biology, Computational Biology, Statistics, Machine Learning, or a related technical discipline
• PhD and 2+ years of relevant research experience in developing machine/deep learning-based solutions and a sincere interest for computational life sciences
• Hands-on experience in handling, processing, integrating, and analyzing large heterogenous biological data sets related to industrial drug discovery research (e.g., sc/snRNAseq, ATAC-seq, genomics, proteomics, etc.)
• Proven expertise in developing machine learning for computational biology
• Highly creative person with outstanding problem-solving skills to tackle complex analysis tasks in a timely fashion
• Strong publication record and demonstrated contributions to the field
• Solid expertise with ML libraries such as PyTorch, Lightning is mandatory! Programming skills in Python must be top-notch. Experience with relevant libraries of the Python scientific stack is a big plus.
• Familiarity with GPU computing both on-premises and on cloud platforms
• Fluency with common version control tools and collaborative coding
• Passion and curiosity for data and proven ability to take ideas from prototype to production
• Strong interpersonal skills, distinct collaborative attitude, excellent written and verbal communication

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform mathematical calculations and ability to perform complex data analysis. Relocation support available.

Relocation assistance may be available based on business needs and/or eligibility.

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Obesity is a growing health and economic burden worldwide. It is risk factor for other co-morbidities including heart disease, stroke, Type 2 Diabetes Mellitus (T2DM), certain types of cancer, and higher mortality risk from COVID-19 infection. The Internal Medicine Research Unit (IMRU) is seeking a highly motivated non-PhD scientist with in vivo and molecular biology experience to support preclinical drug discovery efforts around obesity. The ideal candidate will be able to design and execute experiments, as well as analyze, interpret, and effectively communicate results. The candidate will work closely with their manager and other IMRU Pfizer scientists to support exploratory and portfolio efforts.

How You Will Achieve It

• Perform in vivo/ ex vivo/ in vitro experiments.
• Conduct molecular biology experiments such as but not limited to transfection, gene expression analysis, immunostaining, ELISA and Western blotting.
• Capable of following assay protocols and analyzing and interpreting data.
• Compliance to laboratory safety and electronic notebook standards.
• Work effectively with peers to support projects.
• Identify and report any experimental problems, proactively troubleshoot causative factors, and implement necessary corrections following discussion with supervisor.

Qualifications

Must-Have

• Bachelor’s degree in biology, pharmacology, biochemistry, molecular biology or other related discipline
• At least 3 years of lab experience in academia or in industry for Bachelor's.
• Comfortable working with rodents (minimum: handling, dosing)
• Familiarity with standard cell and molecular biology methods including but not limited to cell culture, siRNA and plasmid transfections, lentivirus preparation and transduction, immunoassays such as ELISAs and western blotting, and quantitative real-time PCR.
• Ability to use appropriate software to perform data analysis.
• Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, strong motivation with a dedicated work ethic.
• Excellent verbal and written communication skills.
• Creative, self-motivated and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.

Nice-to-Have

• Experience with in vivo food intake/ body weight studies; or measurements of physical function (max force, treadmill running).
• Knowledge of metabolism and pharmacology.
• Experience working in or collaborating with industry.

PHYSICAL/MENTAL REQUIREMENTS

Ability to work in vivarium with rodents

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

ROLE SUMMARY

The Cash Management activity is a key treasury focus. Treasury Operations Team primarily supports the U.S. market (Pfizer Inc. and all its majority-owned or controlled, U.S. affiliates). The team executes and accounts for high-value and time-sensitive payments or receipts related to several initiatives such as business development, debt servicing, share repurchase, dividends and intercompany netting.

ROLE RESPONSIBILITIES

This position entails activities related to the U.S. Cash pool banking structure. This role plays an integral part on the Treasury Operation team in designing and implementing enhancement to the Treasury function for efficiency. This position is a key liaison to the GBS Teams in Memphis, Tampa, Dalian, and the Dublin Treasury Center. Finally, the position ensure compliance with all SOX and Audit requirement. Provide ad-hoc support to other groups in the Treasury organization (Capital Markets, Corp Strategy etc.) on various technical analytical projects.

Roles and Responsibilities

• Manage bank services and products while fostering relationship at major banking institutions to satisfy the company’s treasury needs within budgeted cost restraints.
• Manage all the bank accounts openings, modifications and closures for Pfizer Inc domestic banking relationships or related services.
• Utilize Cash-pro applications features to group various user groups within Pfizer and streamline new user access, additions, and modifications of user profile.
• Monitor all the ACH and Stop payment controls available at Bank of America and do quarterly review for all preauthorized debits.
• Review and maintain the Treasury Request Manager bank system as aligned with the Pfizer’s System Accord review.
• Quarterly review of LOCs exposure and submit report to the Controllers group.
• Manage and facilitate payment of all US Domestic banking fees to yearly fiscal budgets.
• Review all Letter of Credits, Standby Trust, and Escrow related service fees. 
• Integrate Bank Accounts related to all Acquisition and divestitures.
• Perform back-up role for daily cash liquidity analysis and calculate the daily cash needs and the cash position while adhering to segregation of duties guidelines.
• Perform back-up role in the monthly netting and comp-out process whereby satisfying intercompany cash accounting requirements to the cash position.
• Adhere to full compliance of Audit and SOX requirements for daily accounting and cash management activities.
• Special projects as required within the treasury operations team.

BASIC QUALIFICATIONS

• MBA or BA/BS in Finance, Accounting, Economics, Engineering, or similar quantitative field
• 3-5 years’ experience within Finance/Treasury organization
• Knowledge of Capital Markets with a focus on short term investments (SEC Rule 2A7) and short-term debt (Commercial Paper)
• Knowledge of SOX 404 regulatory requirements
• Excellent written and oral communication skills
• Key attributes include strong analytical & interpersonal skills, detail-oriented individual with a sharp focus on performance and delivery of results.
• Ability to manage and prioritize on numerous tasks, and competing business need and aptitude to maintain focus in a high-pressure environment.
• Pro-actively resolve issues as they arise and to work on their own while understanding limitations.

PREFERRED QUALIFICATIONS

• Certified Treasury Professional (CTP) designation preferred but not required.
• U.S. cash management knowledge is a plus but not required.
• Familiarity with banking platforms, FIS Quantum Treasury Workstation and SAP preferred but not required.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Ability to work during Company Holidays that are not U.S. Banking Holidays.

Other Job Details:

• Last day to apply: March 21, 2024.
• Work Location Assignment: Flexible.

Relocation assistance may be available based on business needs and/or eligibility.

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Working in the Applied Synthesis Technologies group, you will apply cutting edge chemical synthesis capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

We are seeking a creative, highly motivated synthetic organic chemist to join our Pfizer Global Research and Development laboratories based in Groton, CT. As part of the Applied Synthesis and Technology (AST) Group, the successful applicant will contribute to the execution of synthetic technologies (compound library synthesis, high-throughput chemistry screening, biocatalysis, photocatalysis, and flow chemistries) to drive advancement of programs across the small molecule portfolio. The candidate will work directly with medicinal chemistry project teams to generate compound libraries on miniaturized scale and use synthetic technologies to overcome challenging chemistry problems.

How You Will Achieve It

• Design, develop and execute PMC protocols to deliver libraries of analogues of preclinical candidates.

• Carry out a variety of synthesis technologies in support of Pfizer’s small molecule discovery programs.

• As a strong team player, work with partner lines to deliver on project goals via collaboration and clear communication (written and oral).

• Build effective partnerships with other research lines, in particular: analytical, medicinal, and process chemistry.

Qualifications

Must - Have

• Bachelor’s degree in chemistry with at least 3 years’ of experience OR a Masters Degree with 0+ years of experience

• Firm understanding of reaction mechanisms and reactivity and familiarity with a range of reaction types, conditions and scales.

• Knowledge of purification methods and characterization of organic compounds, especially NMR and mass spectroscopy.

Nice to Have

• Theoretical and applied knowledge of chemical synthesis

• A firm understanding of reaction mechanisms and reactivity and familiarity with a range of reaction types, conditions, and scales.

• Knowledge of purification methods and characterization of organic compounds, especially NMR and mass spectroscopy.

• Ability to work independently to solve problems through careful experiment design, data analysis, and mechanistic insight.​

Acts Decisively

• Makes good decisions in a timely manner, sometimes under tight deadlines.

Change Agile

• Capable of quickly adapting to changes in project direction.

• Responds well to scientific challenges and applies significant rigor to their own work.​

Drive and accountability

• Steadfastly pushes self to achieve results and deliver on goals.

Peer relationships

• Is seen as a team player and is cooperative.

• Easily gains support and trust of peers.

• Encourages collaboration.

Relocation assistance may be available based on business needs and/or eligibility.

Why Patients Need You  

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.  

What You Will Achieve  

At Pfizer, we are always seeking to deliver breakthroughs that change patients' lives. In this role, you'll be working to help us achieve that goal by advancing biotechnologically derived products to the market through innovation and delivery of cutting-edge analytical testing. You will be part of a team which is focused on developing methods and strategies to support product and process development for small molecules, at all stages of clinical development. You will work across analytical functions and projects. 
 
A Senior Principal Scientist in Analytical Research and Development plays an important role during all phases of pharmaceutical development. The qualified candidate will take an active role by leading the analytical development strategies and performing and directing lab work for new drug candidates. The candidate will work with cross-functional development teams and apply a variety of analytical methodologies to support physical and chemical characterization of drug substances and products. The candidate should be proficient with a breadth of analytical methodologies (e.g. chromatography, mass spectrometry, dissolution, spectroscopy, and NMR), with expertise in one or more techniques.  The candidate should also be proficient with a wide variety of software and information systems and have a demonstrated ability to learn new techniques and solve complex analytical problems. Experience with mathematical modeling or coding is also desired.  
 
It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.  

How You Will Achieve It  

•  As a project analyst, the candidate will be responsible for developing analytical strategies in support of pharmaceutical drug products during all development phases, including supporting manufacturing process development, developing, validating and transferring analytical methods, designing stability studies to understand drug degradation mechanisms and for shelf life assignments, and developing impurity control strategies.

• The candidate will perform lab work and will plan, direct, and review the lab work of other scientists in a matrix environment.

• The role requires collaboration with colleagues to identify appropriate analytical approaches, including use of computational predictive tools, modeling software and data visualization tools where appropriate.

• The candidate will critically review and Interpret scientific data to derive clear conclusions and provide direction for future work and will communicate results and conclusions through various media including presentations and technical reports.

• As a subject matter expert, the candidate will evaluate new approaches, instrumentation or analytical technologies and mentor other scientists.

• The candidate will author relevant sections of the quality modules of regulatory submissions.

Qualifications  

BASIC QUALIFICATIONS 

• Ph.D in Analytical Chemistry or related field, with 7+ years of pharmaceutical R&D experience required or Masters in Analytical Chemistry or related field, with 10+ years of pharma R &D experience required.

• Demonstrated oral and written communication skills, including visualization of data, presentations and authoring technical articles.

• Demonstrated ability to meet timelines and interact with multi-disciplinary teams

• Demonstrated ability to learn new techniques and solve complex analytical problems.

• Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required.

• Proficient with a wide variety of software and information systems.

PREFERRED QUALIFICATIONS

• Ph.D in Analytical Chemistry or related field, with 7+ years of pharmaceutical R&D experience required

• Working knowledge and the ability to operate analytical techniques such as HPLC-MS, GC-MS, spectroscopy, and physical techniques such as particle size and dissolution that are commonly used for the characterization of pharmaceutical substances and products is desired.

• Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

 
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
 

PHYSICAL/MENTAL REQUIREMENTS

Role requires ability to perform mathematical calculations and complex data analysis.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Role requires adherence to standard operating procedures. Some travel may also be required. Ability to work in a laboratory setting

Additional Information:

• Relocation support available
• Eligible for Employee Referral
• Work Location Assignment: On Premise
• Last Day to Apply: March 21, 2024

Relocation assistance may be available based on business needs and/or eligibility.

ROLE SUMMARY

The Internal Medicine Research Unit (IMRU) is committed to finding cures for metabolic diseases and related complications. Our goal is to build a research team of driven scientists focused on developing a deep mechanistic understanding of the metabolic pathways driving obesity, cardiovascular disease, diabetes, and renal disease. Apply scientific and technical expertise to drug discovery programs to impact the future of new drug candidate development. The aim is to recruit a scientifically and technically strong research scientist proficient in in vivo and in vitro metabolic research models, with the ultimate goal of developing effective therapies.
 

ROLE RESPONSIBILITIES

• Conceptualize and design experiments.

• Organize and conduct in vitro/ in vivo/ ex vivo studies independently (including preparation, data collection, interpretation, and presentation).

• Maintain awareness of scientific and technical developments in the field.

• Author manuscripts for quality publications in top-tier journals.

• Interface with an interdisciplinary team of scientists in the Internal Medicine Research Unit and engage in both target exploration and driving established projects in our portfolio.

• Quantify and translate experimental results to advance the understanding of how metabolic pathways and complex physiological systems are altered by diseases and how they respond to therapeutic interventions.

• Maintenance of laboratory notebook records and adherence to safety policies is strictly required.

QUALIFICATIONS

• PhD with a minimum of 2 years of post-doc experience.

• Experience in obesity-related physiology is required (examples, CNS regulation of energy balance, muscle or adipose metabolism/function).

• Expertise in cell biology and physiology with emphasis on metabolism and signaling pathways is essential.

• Experience working with GPCRs and associated pathways is a plus but not required.

• A successful track record of scientific achievements through scientific publications and presentations.

• Candidate should be able to review literature to formulate new ideas and have the ability to work independently as well as with an interdisciplinary team of scientists in a highly collaborative environment.

• The candidate will have daily interactions with a team of creative and innovative scientists in a supportive environment.

• Excellent communication and interpersonal skills are essential.

  
PHYSICAL/MENTAL REQUIREMENTS

In vivo vivarium work

Relocation support available

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Position Summary

A Senior Scientist in the Compound Management (CM) Data Support team plays an important role in the stewardship of the Pfizer compound collection specializing in solutioning, data flows, and material workflows & logistics. You will collaborate with the Primary Pharmacology Group (PPG), hit follow-up, lead optimization, External Research Solutions, and Medicinal chemistry stakeholders, to ensure timely, high-quality access to the Pfizer compound collection.  Partnerships with Digital, Contract Research Organizations, and external software & hardware vendors are also a key aspect of the role.  As a senior member of the CM Data Support team, you will also have significant input in defining plans and strategy for the team.

Key Responsibilities

• Collaborate with stakeholders, both internal & external, to analyze business requirements and design & implement lab-specific information & data-driven solutions.

• Provide daily technical subject-matter-expert expertise, troubleshooting assistance and guidance on the applications and tools, both at the enterprise level & lab specific level, that support CM workflows to other CM colleagues and internal stakeholders.

• Collaborate and partner with Pfizer Digital to develop lab-specific solutions that address CM workflow, data mining, analysis, storage, and curation requirements, and adhere to Digital enterprise level requirements, such as security, change & configuration management.

• Participate in CM project teams as a key contributor by providing insight & expertise on data handling, applications, laboratory automation & material logistics to solve issues of significant complexity and improve the efficiency of operations in Compound Management.

• Produce high-quality and detailed documentation for implemented solutions, including workflow & data diagrams, description of requirements, use cases, design, tests, users guides & standard operating procedures.

• Participate in the evaluation and testing of internally and externally developed tools and applications, providing expertise in the planning, execution, recording and reporting of results.

• Contribute to the strategic direction, daily decision-making, and operation of Compound Management, focusing on compound stewardship, efficiency, quality assurance and continuous improvement by effectively collaborating with other Compound Management teams, such as the Liquid Store, Sample Logistics, and Automation.

• Identify and champion new ideas and technological strategies that will enable innovation, continuous improvement and capability enhancements in workflows and operations within Compound Management.

• Present technological advancements & solutions internally to Compound Management stakeholders and externally to industry peers.

• Act as a technical and scientific resource within Compound Management’s data support team.

• Mentor junior team members by modeling courage & excellence in your work and contributing to an environment of equity and joy that promotes active engagement & learning.

Minimum Qualifications

• Bachelor of Science degree in Computer Science, Data Science, Information Science, Engineering, or a related field with 9+ years of relevant experience in developing solutions.

• Expertise in databases (Oracle/PostgreSQL), query languages (SQL/PLSQL), and database navigation/management tools (Toad/DBeaver).

• Experience leveraging many of the following tools & technologies:  Pipeline Pilot, SharePoint Pages/Web Parts/Power Apps, Excel Macros/Visual Basic & Diagramming Tools (Visio/Draw.io).

• Demonstrated ability to develop innovative and creative solutions applying agile & lean principles to solve complex issues to streamline workflows and minimize risks for errors.

• Comprehensive working knowledge of Microsoft applications, including Outlook, Excel, Word, PowerPoint & Teams.

• Demonstrated experience collaborating with stakeholders and external hardware & software vendors.

Preferred Qualifications

• Master’s degree in Computer Science, Data Science, Information Science, Engineering, or a related field with 7+ years of relevant experience in developing laboratory solutions in the pharmaceutical industry.

• Expertise leveraging many of the following tools, languages, & technologies: LIMS Systems/Software, Java/C#, Scripting (JavaScript/Python/Perl), HTML/XLM/JSON, APIs (REST/Soap/Microservices), Jira, Confluence, Eclipse, GitHub/SVN.

• Prior experience in pharmaceutical laboratory automation, specifically, in the operation of liquid handling systems, storage systems and other automated tube & plate handling instrumentation.

• Experience working in areas of compound management or research materials logistics.

• Basic understanding of primary pharmacology assay development and compound screening is a plus.

PHYSICAL/MENTAL REQUIREMENTS

Position will require working in the lab, operating automated equipment, lifting, sitting, standing, walking, bending and the ability to perform mathematical calculations and solve complex technical problems.

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.