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University of Edinburgh

8797 - Postdoctoral Research Associate

Full-time

Edinburgh, Scotland, England

Education / Training

10 months ago

Postdoctoral Research AssociateGrade: UE07Salary range: £37,099 - £44,263School: School of MathsContract Type - Fixed Term - 24 m.....

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University of Edinburgh

9127 - Postdoctoral Research Associate

Full-time

Edinburgh, Scotland, England

Education / Training

10 months ago

UE07, £37,099 - £44,263 per annumCollege of Science and Engineering/School of Physics and Astronomy/Institute for AstronomyFixed.....

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University of Edinburgh

9218 - Postdoctoral Research Associate

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

Grade UE07: £37,099 - £44,263 per annumCollege of Science and Engineering / School of Biological Sciences / Institute of Quantita.....

Grade UE07: £37,099 - £44,263 per annum
College of Science and Engineering / School of Biological Sciences / Institute of Quantitative Biology, Biochemistry and Biotechnology
Full-time: 35 hours per week
Fixed-term: for 24 months

We are looking for a driven and enthusiastic post-doctoral researcher interested in working on the post-transcriptional roles of Helix-Turn-Helix transcription factors in an important bacterial pathogen (MRSA).

The Opportunity:

We recently found that many Helix-Turn-Helix domain transcription factors (HTH-TFs) from methicillin-resistant Staphylococcus aureus also globally bind RNA in vivo. Some HTH-TFs have well-established transcriptional roles in regulating MRSA infectivity and antibiotic resistance. Moreover, the transcription activity of numerous HTH-TFs can be controlled by small molecules, making them promising targets for developing novel antimicrobials.

Our data indicate that the regulatory impact of HTH-TFs is much more profound than anticipated, underscoring the need for a thorough characterisation of these proteins. We hypothesise that HTH-TFs post-transcriptionally control a substantial fraction of antibiotic resistance and virulence factors by altering the stability/translation of RNA substrates. RNA may also compete with HTH-TF transcriptional activities.

By integrating state-of-the-art biochemical, structural, and phenotypic approaches, you will obtain detailed mechanistic insights into (i) how key HTH-TFs bind both DNA and RNA molecules, (ii) how small molecule effectors control this activity, and (iii) how these RNA-binding activities impact gene expression during host infection. A detailed understanding of MRSA HTH-TF function and how its nucleic acid binding is regulated may underpin future therapeutic approaches.

Your skills and attributes for success:

Experience in structural and biophysical characterisation of protein-nucleic acid interactions.
Experience with analysis of large datasets using Python and/or R.
Demonstrated background in RNA Biology research.
Experience in biochemical approaches for studying protein-nucleic acid interactions.
Understanding of co- and post-transcriptional regulation of gene expression.

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The City of Edinburgh Council

Teacher of Mathematics - Liberton High School - EDN26295

Full-time

Edinburgh, EH17 7PT, England

Education / Training

11 months ago

Job DescriptionChildren, Education and Justice Services Teacher of Mathematics - Fixed term until 30/09/2025Liberton High School.....

Job Description

Children, Education and Justice Services

Teacher of Mathematics - Fixed term until 30/09/2025
Liberton High School

Salary: £31,584 - £47,565 per year
Hours: 35 per week

We are a successful school, which is evident in our attainment journey over the past 5 years. Liberton serves a socially diverse community where 70% of our students live in quintile 1 and 2 of the Scottish Index of Multiple Deprivation, and many of our families join us from a variety of different countries and cultures. This all adds to our pride in that our School represents a community where each individual is valued and respected and welcome for who they are.

Our core school belief is that ‘Everyone Matters’ this is visible and lived by pupils, staff and families. It is underpinned by our values of Ready, Respectful and Responsible. We believe in positive relationships for learning, and that every person has the right to achieve, and exceed their potential.

Due to staffing changes within the department, we are looking to appoint a highly skilled and motivated Teacher of Mathematics. We are looking for a candidate who can add their experience and knowledge to existing teaching and introduce new ideas and strategies appropriate to our learners.

Salaries will be in accordance with the Scheme of Salaries and Conditions of Service for Teaching Staff in School Education.

This post is regulated work with children and/or protected adults under the Protection of Vulnerable Groups (Scotland) Act 2007. The preferred candidate will be required to join the PVG Scheme or undergo a PVG Scheme update check. Where an individual has spent a continuous period of 3 months or more out with the UK in the last 5 years, an Overseas Criminal Record Check will be required. You will be required to provide this check. An unconditional offer of employment and commencement in the post will be subject to the outcome of both these pre-employment checks being deemed satisfactory.

We're committed to creating a workplace culture where all our people feel valued, included and able to be their best at work, and we recognise the benefits that a diverse workforce with different values, beliefs, experience, and backgrounds brings to us as an organisation.

Proud member of the Disability Confident employer scheme

About Disability Confident

A Disability Confident employer will generally offer an interview to any applicant that declares they have a disability and meets the minimum criteria for the job as defined by the employer. It is important to note that in certain recruitment situations such as high-volume, seasonal and high-peak times, the employer may wish to limit the overall numbers of interviews offered to both disabled people and non-disabled people. For more details please go to Disability Confident.

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University of Edinburgh

9222 - Research Technologist-Synthetic Biology

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

Grade UE07: £37,099 - £44,263 per annumCollege of Science and Engineering / School of Biological Sciences / Institute of Quantita.....

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University of Edinburgh

8973 - Research Fellow (ADVANCE-D)

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

Grade 7, Salary Range £37,099 - £44,263 - Appointment will be made at Spinal Point 30-32 (£37,099.00-39,347.00 pro rata) due to f.....

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University of Edinburgh

8993 - Science Outreach Assistant

Full-time

Edinburgh, Scotland, England

Science / R&D / Research

11 months ago

UE02: £21,900 per annumPublic Engagement, Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Ve.....

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University of Edinburgh

9117 - Research Finance Administrator

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

Grade UE05: £25,742 - £229,605 per annumCAHSS / Edinburgh College of Art / ECA OfficeFull-time: 35 hours per weekFixed-term: 12 m.....

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University of Edinburgh

9113 - Image Analysis Research Assistant

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

UE06, £31,316 - £36,024CMVM, Deanery of Clinical Sciences, Centre for Clinical Brain Sciences Full time, 35 hours per week12 mont.....

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University of Edinburgh

9067 - Research Assistant

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

Grade 6, salary range: £31,396- £36,024College of Science and Engineering, School of Informatics Full time 35 hours per weekFixed.....

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University of Edinburgh

8496 - Clinical Research Funding Specialist

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

UOE - Grade 6 £31,396- £36,024School/Department - Edinburgh Research Office, Corporate Services Group Contract Type - Full time (.....

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University of Edinburgh

9046 - Postdoctoral Research Fellow

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

UE07: £37,099 - £44,263CMVM/Edinburgh Medical School/Deanery of Biomedical Sciences/Centre Discovery Brain Sciences/UK Dementia R.....

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University of Edinburgh

9063 - SIDB Postdoctoral Research Fellow

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

UE07 £37,099 - £44,263 Per AnnumCollege of Medicine and Veterinary Medicine / Edinburgh Medical School / Deanery of Biomedical Sc.....

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University of Edinburgh

8937 - Teaching Fellow in Health in Social Science

Full-time

Edinburgh, Scotland, England

Accounting / Auditing

11 months ago

Teaching Fellow in Health in Social ScienceCounselling, Psychotherapy and Applied Social SciencesSchool of Health in Social Scien.....

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University of Edinburgh

8948 - Research Fellow

Full-time

Edinburgh, Scotland, England

Education / Training

11 months ago

UE07, £37,099 - £44,263 per annumCollege of Medicine & Veterinary Medicine, Deanery of Clinical Sciences, Centre for Cardiova.....

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