Job Title and Reporting: Research Technician (1x FTE)

Grade of Post/Salary: Grade 5 £25,138 - £28,759 Reporting Line Manager: Professor James Chalmers Duration of employment: 24 months

Location: School of Medicine, Ninewells Hospital

The Respiratory Research group at the University of Dundee specialises in studies into the immunology and microbiology of respiratory diseases such as bronchiectasis, COPD and pneumonia. You will be expected to provide high quality technical assistance to Professor Chalmers and the other members of the research team. As a research technician you will play an important role in studies with direct benefit to patients such as clinical trials and patient cohort studies working alongside other research technicians within the group and overseeing the timely completion of research projects in partnership with the principal investigator, postdoctoral researchers and other research staff.

Core laboratory tasks may include processing biological samples, culture of airway epithelial cells at air liquid interface, microscopy, ELISA, and preparation of cells and biological samples for downstream processing such as flow cytometry and proteomics. You will support the principal investigator, post- doctoral researchers and PhD students as part of a multidisciplinary team. You will work collaboratively with team members to support multiple ongoing research studies where appropriate. You will work with external collaborators and internal department such as the Clinical Research Centre and core facilities to ensure the timely completion of research studies.

We are recruiting for an exceptional individual to join us as a Postdoctoral Researcher within The Stanley-Wall Laboratory, Molecular Microbiology, School of Life Sciences, with experience in bacterial genetics, transcriptions and/or microscopy (https://www.dundee.ac.uk/people/nicola-stanley-wall). This is a fixed-term appointment for up to 42 months.

We investigate mechanisms underpinning Bacillus subtilis biofilm formation and conduct interdisciplinary studies combining classical molecular genetics, microbiology, and soft matter physics.

We aim to uncover key regulatory mechanisms underpinning Bacillus subtilis biofilm matrix remodelling, function, resilience, and competitiveness, that direct the ability of this organism to occupy a wide range of environmental niches. The successful applicants will exploit recent findings to uncover the molecular processes driving adaptation of the biofilm matrix and the impact for the function and success of the bacteria in different environments.

The project builds on our published work (see https://pubmed.ncbi.nlm.nih.gov/36528619/; https://pubmed.ncbi.nlm.nih.gov/34486975/). You will be part of a collaborative research project with colleagues based at the University of Edinburgh (Prof. Cait MacPhee and Dr. Ryan Morris).

The appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case, the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 25 - 28).

To apply, please submit a single PDF file that contains:

• A cover letter that outlines your research interests and career goals, alongside a summary highlighting your expertise in microbial genetics and gene expression analysis.
• A curriculum vitae containing a list of publications and/or preprints with a brief description of your contribution to each piece of work.

It is intended that interviews for short listed candidates will be held on the 18th and/or 19th of November 2024.

Your priorities will include:

• Transcriptomic analysis of Bacillus subtilis biofilms in different environmental context
• Analysis of B. subtilis survival and adaptation to different contexts
• Engaging members of the public in our research

Who we're looking for:

Successful candidates will have a strong background in bacterial genetics, ideally with expertise in transcriptomics and/or microscopy. You should be creative, enthusiastic to solve challenging problems, be a team player, be equipped with excellent communication skills and have an awareness of working in a positive research culture.

Candidates are expected to have expertise in:

• Molecular biology, bacteriology
• Transcriptomic analysis

And/or

• Flow cytometry
• Microscopy
• Knowledge of biofilm formation Additional desired skills are:
• Undergraduate student supervision in laboratory settings
• Tutoring undergraduates

For further information about this position please contact Prof Nicola Stanley-Wall (Molecular Microbiology/School of Life Sciences) at n.r.stanleywall@dundee.ac.uk. To find out more about the Division of Molecular Microbiology (MMB) please visit https://www.dundee.ac.uk/life-sciences/research/molecular-microbiology

We are recruiting for a Grade 5 Research Technician

An opportunity has arisen for a research technician to join us within the Jackson Lab at the University of Dundee. This group will be exploring the role of Apolipoprotein E in Alzheimers Disease with an aim to target this important protein to prevent against Alzheimers Diseases.

You will be expected to provide high quality technical assistance to Dr Rosie Jackson and the other members of the research team. Core tasks will include culture of induced pluripotent stem cells derived astrocytes, HEK 293 cells, and primary astrocytes, and multiple molecular techniques including Maxiprep, ELISA, as well as in house assays of inflammation and protein thermal melt.

You will work with the principal investigator and overseas collaborators, performing laboratory research to a high standard and organising study data. You will work collaboratively with other team members including Postdoctoral fellows and PhD students to develop and validate protocols for sample collection and support curation of samples in long-term storage whilst supporting recruitment and sample collection to newly set-up clinical studies. You will be expected to work with the principal investigator to deliver research studies to a high standard in a timely manner.

The University of Dundee enjoys an international reputation for excellence that attracts top-class students and academics from across the world - with over 140 countries represented in the University community. You will be based in the medical sciences institute building at the School of Life Science. The group is part of the School of Medicine which provides outstanding medical education and training supported by world class research facilities.

Your priorities will include:

• Provide technical research support to the ApoE research group.


• Carry out laboratory-based research to a high standard.


• Work under the supervision of the principal investigator but assume responsibility for your projects.


• Maintenance of cell culture lines


• Deriving Astrocytes from induced pluripotent stem cells.


• Using various in-house assays to test drug compounds in vitro.


• Managing laboratory reagent stocks


• Contribute to group meetings an work collaboratively within the lab.

Who we're looking for:

• Proven ability to work in a multidisciplinary science team to deliver high quality research


• Experience with IPS cells is highly desirable but not a requirement.


• Ability to collaborate with members of other research groups within the University and other academic institutions.


• Capable of interpretation of raw data, assembly into summary reports and presentation to staff.


• Ability to work to deadlines and to meet milestone targets, with detailed attention to time management and multitasking.


• Flexibility and willingness to work outwith normal hours as and when required.

This role does not meet the minimum requirements set by the UKVI to enable sponsorship of migrant workers. Further information can be found at: https://uod.ac.uk/2qUx1RR

For further information about this position please contact Dr Rosie Jackson at rjackson001@dundee.ac.uk .

The closing date for applications 25th of November.

At the University we benefit from having access to a range of personal and professional development courses and training opportunities, we enjoy 34 days annual leave per year and are supported by a range of Work Life Balance policies, staff support networks, membership of Athena SWAN and Stonewall as well as a full range of disability services which all create an enjoyable and inclusive place to work. It is the diversity of our staff and students that make the University of Dundee an enjoyable place to work.

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 40 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

We are recruiting for exceptional individuals to join us as postdoctoral research assistants within our Biological Chemistry and Drug Discovery Division, to work in the area of trypanosomatid molecular biology. This is a fixed-term appointment for up to 16 months.

We are looking for highly motivated researchers with appropriate skills in molecular and cell biology to work in the area of trypanosomatid molecular biology. The project is funded by Wellcome and a major goal is to understand gene expression control in African trypanosomes (see https://sites.dundee.ac.uk/david-horn/).

Projects may focus on gene expression control by RNA-binding proteins, expression of Variant Surface Glycoprotein related genes, or core histone tail editing.

Candidates interested in parasites that cause neglected tropical diseases and in applying state-of-the-art genetic technologies to these parasites should apply.

Please note that applications made on a part-time basis for this role will/will not be considered.

Your priorities will include:

• To pursue a research project involving predominantly molecular genetic and cell biology techniques.


• Work independently, and contribute to the teaching/training of other staff/Ph.D. students.


• Contribute to the life of the School of Life Sciences

Who we're looking for:

Essential:

• A PhD in a relevant subject


• Significant experience contributing to molecular biology projects in the laboratory


• Publication(s) in peer-reviewed journals


• Ability to work independently and/or as part of a team


• Experience with cell culture Desirable:


• Experience with containment level two pathogens


• Computer and data processing skills


• Good communication skills, both written and verbal

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Professor David Horn d.horn@dundee.ac.uk To find out more about Group/Unit/Team/School please visit the Website.

Commitment to DORA

The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

We are recruiting for an exceptional individual to join as a Postdoctoral Researcher in the laboratory of Dr Arpan Mehta. This is a fixed-term appointment for 18 months, with potential extension at the end of the term.

We are recruiting for a driven individual to join the laboratory of Dr Arpan Mehta, a clinician-scientist, with expertise in cell biology and/or gene-editing to conduct an innovative pooled CRISPR screen in human motor neurons derived from induced pluripotent stem cells. The overarching goal of the lab is to undertake fundamental research to understand the molecular basis of amyotrophic lateral sclerosis (ALS), a form of motor neuron disease (MND), through open and interdisciplinary collaborations within and outwith of our unit.

The successful applicant will undertake a project as part of the MND Accelerator (MNDAcc) initiative funded by the Medical Research Council and National Institute for Health and Care Research to make the translation of discoveries into therapeutics easier for motor neuron disease and frontotemporal dementia. The goal is to make robust discoveries and share data openly in the space of 18 months.

Your priorities will include:

• Build C9ORF72-iCas9 iPS cell line and perform quality control followed by differentiation to motor neurons and microglia using published protocols.
• Optimise and perform a kinome-wide CRSIPR/Cas9 knock out-screen and sgRNA enrichment analysis.
• Validate the top candidate hits and create a CROP-seq library in partnership with UK Dementia Research Institute (UK DRI) single-cell facility.
• Public and patient involvement and engagement presentations.
• Dissemination of protocols and data openly and through formal peer-reviewed publications.
• Advising and mentoring undergraduate and PhD students.

Candidate requirements:

• PhD in molecular biology with a track record of academic success.

• Highly organised, motivated and meticulous, with an ability to work independently and to drive a project forwards robustly and at pace.
• Expertise in iPS cell culture is highly desirable, although the successful candidate would be supported and trained (if necessary) by Dr Lindsay Davidson who leads our iPSC core facility.
• Prior experience in gene editing and CRISPR screens would be highly desirable.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Dr Arpan Mehta at amehta001@dundee.ac.uk. To find out more about MRC PPU please visit https://www.ppu.mrc.ac.uk/

We are recruiting highly motivated postdoctoral researchers to participate in a new academic-industrial global initiative supported by the Michael J Fox Foundation for Parkinson's Research. The project aims to: (1) Explore and validate new approaches to target LRRK2; (2) Perform systematic mechanistic, structural and safety analyses to benchmark new LRRK2 modifiers that emerge from this effort and (3) identify clinically relevant biomarkers for LRRK2-driven Parkinson's disease that will facilitate the selection of patients who respond to LRRK2 inhibitor therapy. We aim to galvanise research and accelerate the development of Parkinson's disease therapeutics. These positions enable further training in state-of-the-art methods through the course of the project, and involve wider collaboration with Protein Phosphorylation and Ubiquitylation Unit members, other academic Institutions worldwide and industrial partners working in this area.

The appointed post holders will be based within the laboratories of Dario Alessi, Esther Sammler and Paul Davies within the University of Dundee's MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU, http://www.ppu.mrc.ac.uk/).

The successful applicant will have previous knowledge and expertise in one or more of the following areas:

1. Mechanistic cell biology employing a multidisciplinary approach including molecular, biochemical, physiological, mass spectrometry, pharmacological and genetic methodologies.


2. Screening and characterisation of compounds in in vitro and in vivo assays.


3. Protein purification.


4. Structural biology.


5. Computational and AI modelling for hit discovery and optimisation.


6. Biophysical assays to investigate protein/protein interactions and for compound screening.


7. Quantitative mass spectrometry analysis (proteomic, lipidomic, metabolomic, post translational modifications), preferably in clinical samples.


8. Bioinformatic methodologies and analysis of large datasets including mass spectrometry data.

Your priorities will include:

• 
  
  
  
  • To lead a research project in the relevant discipline area using the appropriate methods and/or techniques.
  
  
  • To take responsibility for project development and implementation, including experimental design and identification and development of a broad range of techniques necessary to achieve the research objectives.
  
  
  • To collaborate with research colleagues and support staff internally as appropriate to the research.
  
  
  • To provide guidance and support to other staff and students associated with the project.
  
  
  • To support the production of research reports and/or publications as required by the funding body or for dissemination to the wider academic community.
  
  
  • To undertake any other duties relevant to the programme of research as required.
  
  
  
  

Who we're looking for:

• 
  
  
  
  • Applicants must have a PhD in a relevant discipline with strong academic track record and at least one first authored publication either submitted to a preprint server or published in an internationally recognised peer-reviewed journal.
  
  
  • Significant hands-on expertise in one or more of the following: biochemistry, mass spectrometry, cell biology, molecular biology, structural biology, signal transduction, data analysis and bioinformatic analysis.
  
  
  • Strong knowledge and interest in understanding pathways that are linked to neurodegeneration and Parkinson's disease and an appreciation of how research in this area can be exploited to accelerate drug discovery.
  
  
  • Hands-on experience in experimental techniques and data analysis that are relevant to the role.
  
  
  • Experience in independent research projects including interdisciplinary work.
  
  
  • Ability to work in a team in a highly collaborative manner, embracing the principles of Open Science.
  
  
  • Excellent interpersonal and organisational skills.
  
  
  • Excellent knowledge of the English language is essential.
  
  
  • Experience in multi-institutional and/or industry collaborations is highly desirable.
  
  
  
  

We are seeking a Postdoctoral Research Assistant (PDRA) with expertise in participatory approaches and a background in urban, environmental, or sustainability research to join the Horizon Europe/UKRI-funded Urban ReLeaf project. This interdisciplinary role focuses on participatory design, community engagement, and knowledge exchange, aimed at shaping future cities through citizen-driven data gathering and insights.

Key responsibilities include the design and facilitation of workshops, evaluation and exploitation of research, stakeholder engagement, and collaborating on research outputs, reports and deliverables. You will play a significant role in contributing to the project's impact while supporting your own professional development.

We offer a dynamic, collaborative work environment where you'll join a growing team of design research, urban design, and environmental experts, supported by project partners. You'll gain valuable experience with Horizon Europe projects, enhancing your knowledge of international research and partnerships. We provide opportunities for travel, professional growth, and development, all within a supportive team culture.

This is a fixed-term contract until 31 December 2026 with scope to offer flexible working hours. A full job description is attached.

Further information on Urban ReLeaf can be found here: https://www.urbanreleaf.eu

Your priorities will include:

• Designing and facilitating collaborative stakeholder activities, including workshops, and activities for community engagement across six cities.
• Leading and supporting citizen data collection initiatives, data analysis, and the synthesis of lessons learned.
• Contributing to the establishment and facilitation of a Community of Practice (CoP) focused on urban futures.
• Supporting the development and evaluation of research outputs, reports, and publications that enhance project sustainability and impact.
• Collaborating on interdisciplinary research, producing high-quality deliverables and contributing to team management.

Who we're looking for:

• A Ph.D. in Urban Design, Planning, Environmental Science, or a related field.
• Demonstrated experience in qualitative research and quantitative data analysis, with a proven track record of research publications.
• Strong facilitation skills for stakeholder engagement, with expertise in participatory design and an understanding of citizen science approaches.
• Excellent communication and interpersonal skills, with the ability to manage multiple tasks and work both independently and collaboratively.
• Proficiency in project management and collaboration tools (e.g., Microsoft Office, Miro, Trello) and researchspecific tools for data analysis and visualisation.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Mrs Fiona Fyffe-Lawson at Research and Finance Admin lead e-mail: f.j.fyffelawson@dundee.ac.uk.

To find out more about Group/Unit/Team/School please visit Website https://urbanreleaf.eu/.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

The Finance and Procurement Directorate is responsible for the management of the University's financial affairs with the vision to protect, build and enhance the University's financial position. It contributes to the strategy and direction of the University and provides financial advice and support.

We are recruiting for an exceptional individual to join us as a Research Finance Officer within Finance and Procurement Directorate, to work as part of the Research Finance Services team, you will provide support and guidance to the University academic community and NHS Tayside staff on the end-to-end processes involved in the preparation and submission and post award management of research grants. This is a full-time permanent Appointment

As a finance professional, this position will suit an individual who enjoys working collaboratively to offer research finance support over a range of service areas and who upholds the University's values of: valuing people; working together; integrity; making a difference; and excellence. The successful candidate will have demonstrable experience of building positive relationships with finance and non-finance staff and being able to communicate financial information in a clear and accessible manner, both in writing and verbally.

Your priorities will include:

• Provide a first point of contact for all aspects of the research grants application and awards process;
• Provide expert advice on interpretation of funding body terms and conditions and in particular eligible project costs; prepare and review project financial costing scenarios to optimise budget based on the full Economic Costing (fEC) methodology, including the calculation of salary costs and overhead;
• Provide guidance to Pis on the use of various electronic grant application systems; ensure compliance with funding body terms and conditions as well as compliance with University policy and procedure; co-ordinate grant submissions to meet funding body deadlines, including complex multi-disciplinary and/or multi-centre submissions; responsible for approving online applications on behalf of the University;
• Administration of grant awards
• Liaise with colleagues in Research and Innovation Services and/or TASC legal for contractual requirements for awards; liaise with academic staff on all aspects of the grant application/awards procedure; liaise with School Research Administrative Leads to optimise processes and reporting requirements in relation to research awards management

Who we're looking for:

• Good team working skills
• Ability to plan and prioritise own work activities with the ability to react to changing priorities
• Working autonomously with minimal supervision, initiative will be required to ensure operational efficiency around work requirements
• Adaptable and open to change
• Effective communication skills

We are one of the UK's leading universities - internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and­ coming, friendly, compact and affordable city with a rich heritage in design and technology. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

For further information about this position please contact Jules McMenigall at jmcmeniqallOOl @dundee.ac.uk . To find out more about the Research Finance Service department please visit R:s:ad ,:i

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

We are seeking a Postdoctoral Research Assistant (PDRA) with expertise in participatory approaches and a background in urban, environmental, or sustainability research to join the Horizon Europe/UKRI-funded Urban ReLeaf project. This interdisciplinary role focuses on participatory design, community engagement, and knowledge exchange, aimed at shaping future cities through citizen-driven data gathering and insights.

Key responsibilities include the design and facilitation of workshops, evaluation and exploitation of research, stakeholder engagement, and collaborating on research outputs, reports and deliverables. You will play a significant role in contributing to the project's impact while supporting your own professional development.

We offer a dynamic, collaborative work environment where you'll join a growing team of design research, urban design, and environmental experts, supported by project partners. You'll gain valuable experience with Horizon Europe projects, enhancing your knowledge of international research and partnerships. We provide opportunities for travel, professional growth, and development, all within a supportive team culture.

This is a fixed-term contract until 31 December 2026 with scope to offer flexible working hours. A full job description is attached.

Further information on Urban ReLeaf can be found here: https://www.urbanreleaf.eu

Your priorities will include:

• Designing and facilitating collaborative stakeholder activities, including workshops, and activities for community engagement across six cities.
• Leading and supporting citizen data collection initiatives, data analysis, and the synthesis of lessons learned.
• Contributing to the establishment and facilitation of a Community of Practice (CoP) focused on urban futures.
• Supporting the development and evaluation of research outputs, reports, and publications that enhance project sustainability and impact.
• Collaborating on interdisciplinary research, producing high-quality deliverables and contributing to team management.

Who we're looking for:

• A Ph.D. in Urban Design, Planning, Environmental Science, or a related field.
• Demonstrated experience in qualitative research and quantitative data analysis, with a proven track record of research publications.
• Strong facilitation skills for stakeholder engagement, with expertise in participatory design and an understanding of citizen science approaches.
• Excellent communication and interpersonal skills, with the ability to manage multiple tasks and work both independently and collaboratively.
• Proficiency in project management and collaboration tools (e.g., Microsoft Office, Miro, Trello) and researchspecific tools for data analysis and visualisation.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Mrs Fiona Fyffe-Lawson at Research and Finance Admin lead e-mail: f.j.fyffelawson@dundee.ac.uk.

To find out more about Group/Unit/Team/School please visit Website https://urbanreleaf.eu/.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.

We are looking for an exceptional Postdoctoral Research Fellow with strong Cell and Molecular Biology experience to join the Sapkota Lab to work on an exciting & innovative industry-academia collaborative project aimed at targeting membrane receptor and extracellular proteins for degradation through induced-proximity platforms. The field of targeted protein degradation, for example through PROTACs and molecular glue degraders, is emerging as an exciting new modality for research and therapeutics. The fellow will be based in the Sapkota lab (MRC-PPU, School of Life Sciences) and will work in close collaboration with teams at a leading international pharmaceutical company, which is funding this exciting interdisciplinary project. The Sapkota lab has developed several induced-proximity platforms for targeted protein degradation, phosphorylation, and dephosphorylation of intracellular proteins. This project seeks innovative approaches to push the boundaries to achieve proximity-induced degradation of cell membrane and extracellular proteins. This is a unique opportunity to gain experience in world-leading, collaborative and cutting-edge research in one of the hottest areas of modern translational chemical biology and drug discovery. The successful candidate would also be part of an early-stage academia-industry partnership that has exciting prospects for the future. The Sapkota Lab has an outstanding track-record of working with leading pharmaceutical industries, and Prof. Sapkota was recently recognized with the Biochemical Society 2025 Industry and Academic Collaboration Award.

For details of the Sapkota lab research, please visit https://sites.dundee.ac.uk/sapkota-lab/.

For more information, please contact Gopal Sapkota (gsapkota@dundee.ac.uk).

Your priorities will include:

• Project development and implementation of the project in collaboration with the project team that includes the participating pharmaceutical company.
• Development of tools (constructs, cell lines, assays) to monitor receptors and extracellular proteins.
• Performing specificity of degradation and mode of action studies using proteomic approaches.
• Presenting progress reports to the project team every two weeks.
• Discussing scientific work at internal meetings, meetings with DSTT industrial partners and at conferences.

Who we're looking for:

• PhD with an outstanding track record and at least one first-authored publication in an internationally recognised peer-reviewed journal.
• Strong background in cell and molecular biology, biochemistry, and signal transduction, with expertise in ubiquitin signalling and autophagy is desirable.
• Strong background in targeted protein degradation modalities is desirable.
• Capable of working in a diverse team, but able to plan and work independently.
• Excellent communication skills and proficiency in English.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Gopal Sapkota at g.sapkota@dundee.ac.uk.

To find out more about MRC PPU please visit https://www.ppu.mrc.ac.uk/ As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.

We are recruiting for an exceptional individual to join us as a Postdoctoral Research Assistant within our Antigen Discovery Group, to support laboratory-based research in T cell antigen discovery. This is a fixed-term appointment for 3 years.

We are looking for a highly motivated Research Assistant with enthusiasm for T cell immunology and experience in sample preparation, analysis and interpretation of liquid chromatography mass spectrometry (LC-MS)-generated datasets. You will join the Antigen Discovery Group which aims to decipher the molecular architecture of the Human Leukocyte Antigen (HLA) processing and presentation machinery and study the effects of its function on T cell recognition in several disease models, including cancer. Processing samples of a variety of origins using standard lysis and immunoprecipitation, chromatography and mass spectrometry workflows, and data analysis will be an integral part of the position.

The position is central to the Antigen Discovery Laboratory and will support cutting-edge research ongoing in the wider institute. You will have the opportunity to formulate your own research projects and focus. You will have a background in Biology/Biochemistry (or a related discipline) with considerable bench science experience, and ideally with expertise of the analysis of peptides by liquid chromatography tandem mass spectrometry (LC-MS/MS). The post is located at the School of Life Sciences with access to a variety of facilities and its state-of-the-art mass spectrometry facilities. You will join a team of scientist that are passionate about HLA molecules and T cell antigen discovery for the development of next generation immunotherapies.

This postdoctoral research position requires you to hold a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (£32,332-34,980).

Please note that applications made on a part-time basis for this role will be considered.

Your priorities will include:

• Manage your own schedule in the laboratory including sample preparation and cell culture.
• Lead data analysis using existing software packages and integration of further analysis tools into existing pipelines available in the group (training available)
• Oversee the generation of proteomic and immunopeptidome datasets from cells and primary mammalian tissue samples and apply scientific techniques and experimental protocols in the context of internal and external collaborations
• Keep up to date with latest developments in the field and contribute to project planning

Who we're looking for:

• You have a Master's degree or PhD with experience in bench laboratory science
• You have experience in working in a life sciences department, and are interested in contributing to translational research
• You have experience in cell culture and standard methods i.e. immunoprecipitation and nucleic acid extraction
• You have experience or like to gain experience with mass spectrometry-based peptide analysis
• You are interested in the principles of immune-recognition and T cells

For further information about this position please contact Dr Nicola Ternette at nternette001@dundee.ac.uk. To find out more about CSI please visit Cell Signalling and Immunology.

We are looking for an ambitious post-doctoral research fellow who will work in an inter-disciplinary, collaborative project between Dr Nirujogi's laboratory at MRC-Protein Phosphorylation Unit, University of Dundee and Prof Siddharthan Chandran / Dr Selvaraj at UK-Dementia Research Institute at University of Edinburgh. The project aims to identify and develop novel biomarkers for Motor Neuron Disease and related neurodegenerative diseases by exploiting deeply curated patient cohorts

from Anne Rowling Regenerative Neurology Clinic (Edinburgh) and quantitative proteomics by apply state-of-the-art Mass Spectrometry technologies (Dundee). Furthermore, the project involves in collaborating with international consortiums such Global Neurodegenration Proteomics consortium (GNPC), Gates Ventures where we will contribute and access proteomics data from large cohort of patients living with neurodegenerative diseases including motor neuron disease, Alzheimer's disease, Parkinson's disease etc., to identify disease specific biomarkers. The post holder will conduct original research and produce data for high quality publications, grant proposals and dissemination to the public. The post-holder will have opportunity to work in both labs at University of Dundee and Edinburgh. This post is ideally serves as a springboard for those motivated to pursue for independent career fellowships or industry career in future. Our recent publications on this area (PMID: Nirujogi et al., Biochem J, 2021; Fan et al., Acta neuropathol, 2021, Banerjee et al., Science Advances, 2023). The post holder will closely interact with a multidisciplinary team of translational neuroscientists, MND clinicians, drug discovery experts to translate identified biomarkers to MND- SMART clinical trial. We will employ cutting edge transcriptomics and proteomics on state-of-the-art Orbitrap Astral and tims-TOF SCP mass spectrometers and proteogenomic analysis in developing multiplexed targeted PRM assays in clinical samples. This is a fixed-term appointment for 36 months.

Enthusiastic candidate should have recently completed a PhD with a strong background and interest in neurodegeneration and mass spectrometry-based proteomics. The position will be a fantastic opportunity to work alongside with multidisciplinary team employing cutting-edge technologies such as transcriptomics, quantitative proteomics and proteogenomic analysis. The candidate will be part of ongoing collaborative research projects between MRC-PPU Dundee and University of Edinburgh. This opportunity will strengthen their skill sets and career development in clinical proteomics and neurodegeneration.

Location

The post holder will be based within the MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences.

Principal Duties

• Undertaking research aimed at developing a compendium of TDP-43 mediated cryptic exons/peptides in human primary macrophages and clinical samples by employing transcriptomic, quantitative proteomic and proteogenomic analysis.
• Project development and implementation by performing primary cell culture, sample preparation for mass spectrometry analysis. Development of Parallel Reaction Monitoring assays for cryptic peptides.
• Integration of transcriptomic and proteomic data to perform proteogenomic analysis and bioinformatic analysis.
• Serum/plasma sample proteomic preparation, quantitative proteomic data acquisition and data analysis.
• Working closely with other lab members and collaborators and able to present and discuss scientific work at group meetings and scientific conference and meetings with external collaborators.

The post holder will:

• PhD with an outstanding track record with clear evidence of at least one first-authored publication in an internationally recognized peer-reviewed journal

• Strong background in Quantitative proteomics using High-resolution mass spectrometry including sample preparation and database searches using MS-Fragger, DIA-NN and Skyline software suites.
• Strong enthusiasm to neurobiology and neurodegeneration
• Prior experience in developing PRM assay is advantageous but not essential.
• Experience with R or Python and able to write, modify and implement published code and packages for data analysis and visualization.
• Excellent communication and proficiency in English.

Service Delivery

Communication Liaison & Networking

The Post holder will jointly work with Dr. Raja Nirujogi (MRC-PPU) and in collaboration with Prof. Siddharthan Chandran and Dr. Bhuvaneish Selvaraj labs at UK-Dementia Research Institute at University of Edinburgh. The post holder may need to travel for sample collection, attend key collaborative meetings and present research updates on a regular basis.

Decision Making, Planning and Problem Solving

The post holder will have an opportunity to develop independence and execute experiments associated with mass spectrometry method development, contribute to the development of data analysis pipeline.

Team Development

The post holder will be part of Nirujogi lab (MRC-PPU) and conduct collaborative research with Prof. Chandran lab and Dr. Selvaraj labs (UK-Dementia Research Institute at University of Edinburgh). The individual will not supervise other team members.

Knowledge and Experience

The individual will have substantial previous research experience and training and have obtained or expected to obtain a PhD degree. Below we summarise the Knowledge and experience that is required:

• PhD in Biochemistry, MS-based proteomics or related discipline with outstanding academic track record and a publication record in internationally recognised peer-reviewed journals.
• Strong interest in neurodegeneration and clinical proteomics research.
• Strong background in biochemistry, MS-based proteomics and proteomics data analysis
• Strong ability to work independently but with excellent ability to work in a team, and an open and collaborative approach to science.
• Excellent communication skills and knowledge of the English language are essential.

We are looking for an exceptional Postdoctoral Research Fellow with strong Cell and Molecular Biology experience to join the Sapkota Lab to work on an exciting & innovative industry-academia collaborative project aimed at targeting membrane receptor and extracellular proteins for degradation through induced-proximity platforms. The field of targeted protein degradation, for example through PROTACs and molecular glue degraders, is emerging as an exciting new modality for research and therapeutics. The fellow will be based in the Sapkota lab (MRC-PPU, School of Life Sciences) and will work in close collaboration with teams at a leading international pharmaceutical company, which is funding this exciting interdisciplinary project. The Sapkota lab has developed several induced-proximity platforms for targeted protein degradation, phosphorylation, and dephosphorylation of intracellular proteins. This project seeks innovative approaches to push the boundaries to achieve proximity-induced degradation of cell membrane and extracellular proteins. This is a unique opportunity to gain experience in world-leading, collaborative and cutting-edge research in one of the hottest areas of modern translational chemical biology and drug discovery. The successful candidate would also be part of an early-stage academia-industry partnership that has exciting prospects for the future. The Sapkota Lab has an outstanding track-record of working with leading pharmaceutical industries, and Prof. Sapkota was recently recognized with the Biochemical Society 2025 Industry and Academic Collaboration Award.

For details of the Sapkota lab research, please visit https://sites.dundee.ac.uk/sapkota-lab/.

For more information, please contact Gopal Sapkota (gsapkota@dundee.ac.uk).

Your priorities will include:

• Project development and implementation of the project in collaboration with the project team that includes the participating pharmaceutical company.
• Development of tools (constructs, cell lines, assays) to monitor receptors and extracellular proteins.
• Performing specificity of degradation and mode of action studies using proteomic approaches.
• Presenting progress reports to the project team every two weeks.
• Discussing scientific work at internal meetings, meetings with DSTT industrial partners and at conferences.

Who we're looking for:

• PhD with an outstanding track record and at least one first-authored publication in an internationally recognised peer-reviewed journal.
• Strong background in cell and molecular biology, biochemistry, and signal transduction, with expertise in ubiquitin signalling and autophagy is desirable.
• Strong background in targeted protein degradation modalities is desirable.
• Capable of working in a diverse team, but able to plan and work independently.
• Excellent communication skills and proficiency in English.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni. Professional Services directorates are key to delivering the University strategy and driving change across the University.

For further information about this position please contact Gopal Sapkota at g.sapkota@dundee.ac.uk.

To find out more about MRC PPU please visit https://www.ppu.mrc.ac.uk/ As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.

We are recruiting for an exceptional individual to join us as Postdoctoral Research Assistant within the Maniaci Group, to develop chemical probes to uncover the molecular basis of the "cleave to modify mechanism", an unprecedented and exciting new mechanism for protein regulation that the Maniaci lab has uncovered. This is a fixed-term appointment for 24 months in first instance.

The work will focus on understanding the regulation and function consequence of the "cleave-to-modify" mechanism which involves the processing of Ubiquitin-like-domain (UBL) fusion proteins to enable their further modification as a mean to regulate protein biological function. While the mechanism underpinning the conjugation and removal of Ubiquitin is now well understood, not much is known about the proteolytic processing of UBL fusion proteins, and the biology that are revealed and triggered as a result. This project aims to elucidate the enzymatic mechanism and substrate specificity of this previously undescribed process and will involve the design, synthesis and biochemical evaluation of a library of novel benchmark chemical probes.

The successful candidate will be expected to design, synthesize and characterise novel covalent and not covalent peptide like ligands. The qualified best ligands will be developed into a variety of novel bifunctional molecules, that recruit covalently, efficiently and selectively to the protease of interest for a variety of novel bifunctional molecules, that purposes, including structural studies and activity-based profiling. You will join a diverse, fast-paced and collaborative team within the Maniaci Group to contribute to multi-disciplinary project. This is a unique opportunity to gain experience in world-leading, collaborative and cutting-edge research in one of the hottest areas of modern chemical biology and biotechnology. The successful applicant will have the opportunity to be trained and apply state-of-the-art techniques during the project. You will be based within the lab of Dr Maniaci at the MRC-PPU. MRC-PPU is one of the world's most renowned centres for research and protein phosphorylation and ubiquitylation and has an exciting collaborative research environment, equipped to the highest international standards. MRC-PPU has also a long-standing Collaboration with leading pharmaceutical companies.

Your priorities will include

• Design, synthesis and characterization of novel covalent and not covalent peptide like ligands and development of probes


• Undertake research aimed at understanding the molecular basis of the Unbiquintin-like protein - protease interaction by employing structural and biophysical approaches


• Performing protein purification for the measurements of protein-protein interactions


• Project development and implementation, including experimental design; identification and development of a broad range of techniques necessary to achieve the research.


• Working collaboratively and assisting with the training of PhD students and other lab members.


• Presenting scientific work at internal and external meetings and contributing to the preparation of research for publication.

Who we're looking for:

PhD in synthetic organic chemistry with outstanding academic track record and a publication record in internationally recognised peer-reviewed journals.

Strong background in peptide synthesis with expertise in protein chemistry, chemical probes development and establishment of biochemical assays

Strong background in protein expression and structural biology is desirable.

Have a strong ability to work independently but with excellent ability to work in a team, and an open and collaborative approach to science.

Have excellent communication skills and knowledge of the English language are essential.

Project Summary:

Coastal Mangroves in Eastern and Western Africa offer coastal communities much-needed ecosystem services and protection against key climate change risks, including risks to low-lying coastal-ecological systems, risks to terrestrial and ocean ecosystems, and as a result, risks to food security. Coastal communities are particularly vulnerable to climate change impacts because of (1) their location being highly exposed to sea level rise and erosion, (2) poor socio- economic conditions, and (3) their high dependence on mangrove ecosystems. Coastal Mangroves however are highly threatened both by anthropogenic and climate change pressures. The main objective of the project (CoastMan) is co-production and uptake of a Multi-Criteria Decision Support System (DSS) that provides vulnerable communities and decision-makers a knowledge-based decision-making capacity for the restoration and conservation of socio- ecological systems. An interdisciplinary and transsectoral team is established from researchers and stakeholders from across three continents (America, Europe, and Africa), in partnership with vulnerable groups to co-develop and uptake a DSS to promote mitigation and strategies that enhance the adaptive capacities of the mangrove socio-ecological systems in Eastern and Western Africa. Drawing on quantitative and qualitative data from extensive field research in coastal Tanzania and Ghana, extensive literature, and remote sensing, the project will 1) co- develop dynamic maps of drivers and risks of mangrove habitat loss, 2) support locally-led social- ecological and climate resilience through coordinated management of mangrove resources, 3) co-develop sustainable livelihood strategies for coastal communities, 4) co-design a novel multicriteria framework for mangrove restoration and conservation, and 5) co-develop a novel DSS for mangrove socio-ecological systems. We devised a co-production and dissemination strategy so that project outputs will assist in identifying mitigation strategies and enhancing adaptive capacities of the frontline coastal communities, including building their capacity needs in designing climate actions such as restoration and conservation of mangrove ecosystems. Furthermore, the project will lead to improved knowledge and capacity of partner institutions through supporting early career researchers and promoting strengthened collaboration between partners and vulnerable coastal mangrove-dependent communities.

The role:

This role will have three primary components: 1) Social science data collection and analysis including mixed methods such as surveys, interviews, focus groups, co-produced and participatory research. 2) Managing project dissemination, communication and engagement 3) Undertaking general project research tasks, including reviewing literature, assessment of impact and contributing to project meetings. Starting salary expected to be on Grade 7. If the successful candidate does not have a PhD or equivalent experience in a relevant area, appointment will be made to Training Grade 7 (£32,332 - £34,980).

1. Application Requirements

In addition to the online form, applicants must include with their application:

• • Cover letter outlining the candidate's suitability for the role, including how the candidate would contribute to the three key areas of responsibility indicated in the role description.
  • Full Academic CV
  • A sample of the candidate's academic writing (not co-authored, approximately 8 - 10 pages)